myelocyte

Myelocyte on bone marrow preparation, Giemsa stain. Normal morphology: round nucleus, pale cytoplasm.

Prof. Osaro Erhabor · CC BY-SA 4.0

Normal neutrophils in (A)-(D), showing developmental stages of myeloblasts: myeloblasts (A), promyelocytes (B), myelocytes (C) to segmented granulocytes (D), x5k. (E)-(H) Positive myeloperoxidase reactivity of primary granules, x5k.

Ru YX, Dong SX, Liu J, Eyden B. Development of Auer bodies from giant inclusions associated with rough endoplasmic reticulum in acute promyelocytic leukemia. Blood Sci. 2023;5:111-117. PMID: 37228776 · CC BY 4.0

Acute promyelocytic leukemia (APL): Wright-Giemsa and MPO staining of promyeloblasts with Auer rods (arrows). The myelocyte's antecedent stage, arrested in APL.

Ru YX, Dong SX, Liu J, Eyden B. Development of Auer bodies from giant inclusions associated with rough endoplasmic reticulum in acute promyelocytic leukemia. Blood Sci. 2023;5:111-117. PMID: 37228776 · CC BY 4.0

Trilineage hematopoiesis in bone marrow: erythroid, myeloid, and megakaryocytic precursors including myelocyte-stage cells.

Mikael Haggstrom M.D. · CC0

(A) Bone marrow cytomorphology by bone marrow aspirate smear. (B) Karyotype of bone marrow. (C) FISH probe detection of myeloid sarcoma biopsies. (D) FISH probe detection of bone marrow aspirate.

Du Y, Yang K, Ling Y, Zhang Y, Gong Y. A case report of acute promyelocytic leukemia with myeloid sarcoma of the lumbar spine and literature review. Front Med (Lausanne). 2024;11:1507716. PMID: 39911670 · CC BY

Radiologic, histopathologic, cytologic, and bone marrow findings (A) Contrast-enhanced chest CT demonstrates a large mass in the right hilar region (red arrow), accompanied by a large right-sided malignant pleural effusion (yellow arrow) and significant pleural thickening (blue arrow). (B) Immunohistochemical staining of the pleural biopsy specimen reveals strong nuclear positivity for TTF-1 in tumor cells (brown staining, red arrows), confirming an origin of lung adenocarcinoma. (C) Pleural effusion cytology (H&E stain) reveals clusters of adenocarcinoma cells against a hemorrhagic background, exhibiting enlarged, hyperchromatic nuclei and marked atypia (blue and yellow arrows). (D) Bone marrow smear demonstrates marked granulocytic hyperplasia. Myeloblasts (red arrow), plasma cells (blue arrow), and mature eosinophils (yellow arrow) are visible, features consistent with a paraneoplastic leukemoid reaction. CT: computed tomography; TTF-1: thyroid transcription factor-1; H&E: hematoxylin and eosin

Duan Y, Yang Y, Yu H, Zhang C, Wang Y, Ruan M et al. Paraneoplastic Leukemoid Reaction in Lung Adenocarcinoma With Multi-lineage Granulocytic Abnormalities and Eosinophilic Pleural Effusion. Cureus. 2025;17:e97404. PMID: 41431550 · CC BY 4.0

Bone marrow aspirate, showing normal trilineage hematopoiesis: myelomonocytic cells (an eosinophil myelocyte marked), erythroid cells (an orthochromatic erythroblast marked), and megakaryocytic cells.

Mikael Haggstrom M.D. · CC0

Gallery

Papers