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Retinal pigment epithelium

Real pictures of the retinal pigment epithelium delivered by gather.site, each with its paper.

3 pictures and 3 papers.

Gallery

iPSC-derived retinal pigment epithelium (iPSC-RPE) grown on fibrin hydrogel, showing characteristic polygonal cell morphology with pigmentation. (E) Phase contrast image of RPE monolayer; (F) RPE cells showing cobblestone appearance with melanin granules consistent with native RPE morphology. (human (iPSC-derived retinal pigment epithelium); Figure 2, E-F.)

Marmorstein AD et al. 2025, Frontiers in cell and developmental biol · CC BY 4.0

Electron microscopy of human retinal pigment epithelium (RPE) at the lateral border between two adjacent RPE cells. Shows RPE ultrastructure including melanosomes, mitochondria at the basal surface, and tight junctions. Mouse RPE is shown in adjacent panel for comparison. (Homo sapiens; Figure 1.)

Neto MV 2024, Cells · CC BY 4.0

Group I (normal) human eye: representative retinal pigment epithelium (RPE) TEM micrograph from a 55-year-old male with normal bilateral fundus examination. Macular sections showing normal RPE ultrastructure with Bruch's membrane (BrM), RPE cell body, apical microvilli, and melanosomes. (Homo sapiens; Figure 1.)

Thananjeyan AL 2024, Journal of clinical medicine · CC BY 4.0

Papers

  1. Marmorstein AD, Scruggs BA, Knudsen T, Hill M, Kopp FN, Trncic E, et al. Degradable fibrin hydrogels for transplantation of iPSC-derived retinal pigment epithelial cell monolayers. Front Cell Dev Biol. 2025;13:1739620. PMID: 41613944.
  2. Thananjeyan AL, Arnold J, Lee M, Au C, Pye V, Madigan MC, et al. Basal Linear Deposit: Normal Physiological Ageing or a Defining Lesion of Age-Related Macular Degeneration? J Clin Med. 2024;13:4611. PMID: 39200753.
  3. Neto MV, De Rossi G, Berkowitz BA, Seabra MC, Luthert PJ, Futter CE, et al. Daily Light Onset and Plasma Membrane Tethers Regulate Mitochondria Redistribution within the Retinal Pigment Epithelium. Cells. 2024;13:1100. PMID: 38994953.

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