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Megalocyte (macro-ovalocyte)
Real pictures of the megalocyte (macro-ovalocyte) delivered by gather.site, each with its paper.
3 pictures and 2 papers.
Gallery
Peripheral blood film showing microcytosis (black arrow), macrocytosis with macro-ovalocytes (purple arrows), and hypersegmented neutrophils with more than 5 lobes (red arrows) in concurrent iron deficiency and vitamin B12 deficiency anemia. (human (peripheral blood, combined B12 and iron deficiency); Figure 2.)
Busaleh F et al. 2021, Cureus · CC BY 4.0
Peripheral blood film (microscopic view) showing a mixed picture of microcytosis (black arrow), macro-ovalocyte (blue arrow), and hypersegmented neutrophils (red arrows) in a patient with concurrent iron deficiency and vitamin B12 deficiency anemia. (human (peripheral blood, combined B12 and iron deficiency); Figure 3.)
Busaleh F et al. 2021, Cureus · CC BY 4.0
Peripheral blood smear in vitamin B12 deficiency (megaloblastic anaemia). Panel (a): macro-ovalocytes (oval macrocytes, yellow arrow) — large oval erythrocytes characteristic of megaloblastic defects in nuclear maturation — alongside a hypersegmented neutrophil (black arrow, five or more lobes) and a nucleated red blood cell/normoblast (green arrow). Panel (b): a red blood cell containing a Howell-Jolly body (red arrow), a nuclear remnant seen in megaloblastic anaemia. Wright-Giemsa stain. (human (vitamin B12 deficiency, megaloblastic anaemia); Figure 3, a-b.)
Parakh N et al. 2026, Frontiers in nutrition · CC BY 4.0
Papers
- Parakh N, Dewan P. Revisiting the hematological manifestations of vitamin B12 deficiency. Front Nutr. 2026;13:1898533. PMID: 42657046.
- Busaleh F, Alasmakh OA, Almohammedsaleh F, Almutairi MF, Al Najjar JS, Alabdulatif A. Microcytic Anemia Hiding Vitamin B12 Deficiency Anemia. Cureus. 2021;13:e20741. PMID: 35111433.