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Histo

Real pictures of the histo delivered by gather.site, each with its paper.

7 pictures and 7 papers.

Gallery

(A) Low-power view of interface between normal lung and nodule of CSH. (B) Low-power view of histiocytes with abundant eosinophilic cytoplasm containing crystals within alveolar space. (C) High-power view of histiocytes with eosinophilic cytoplasm containing elongated, parallel, fine eosinophilic structures consistent with needle-like crystalloid material. Yellow arrow points to one of the crystals. (D,E) High-power view of histiocytes with eosinophilic cytoplasm containing needle-like crystalloid materials with surrounding lymphocytes and plasma cells. (F,I,J) PAS, CD138 and CD68 stain, respectively. (G,H) Immunohistochemistry for lambda light chain and kappa light chain, respectively. Dual staining pattern. Objective magnifications: (A,B) x4; (C-E) x40; and (F-J) x10. (Figure 4.)

Halim, McGrath, Ampazis et al 2026, Diagnostics · CC BY 4.0

Case 1: Histology. The biopsy of the back lesion (A) (4x, H&E) on low-power shows a partially eroded epidermis with areas of spongiosis and overlying parakeratosis and serum crust. Within the dermis, perivascular inflammation is seen, extending into the mid dermis. B, (20x, H&E) Higher-power highlights epidermal spongiosis and brisk inflammation containing increased numbers of eosinophils. The biopsy of the arm lesion (C) (4x, H&E) shows a discrete area of spongiosis and perivascular inflammation. D, (20x, H&E) Higher power shows prominent epidermal spongiosis with lymphocytic exocytosis and scattered intraepidermal eosinophils. Black arrows demonstrate infiltration with eosinophils both within the epidermis and throughout the dermis. (Fig 2.)

Homer, Isler, Morley et al 2026, JAAD Case Reports · CC BY 4.0

HAZV replication triggers Kupffer cell loss following HAZV infection. (A) Representative immunostaining images of liver sections from HAZV-infected wild-type, IFNAR1-/- and IFNAR1-/- MAVS-/- mice at the indicated time points. Scale bar: 200 um. (B) Representative immunostaining images of liver sections from wild-type and IFNAR1-/- mice at the indicated time points. Scale bars: 50 um. (C) Enlarged images of liver sections from IFNAR1-/- mice shown in (B). Scale bars: 20 um. (mouse (wild-type, IFNAR1-/-, IFNAR1-/- MAVS-/- mice; liver sections at multiple time points following Hazara virus HAZV infection); Fig 4.)

Yamada, Shimojima, Saito et al 2026, PLOS Pathogens · CC BY 4.0

Histopathology of hepatobiliary Langerhans cell histiocytosis (LCH). Top row: Explanted native liver (13 February 2025). (A) Hematoxylin and eosin (x200) showing dense histiocyte-like infiltration of the bile-duct walls with admixed lymphocytes. (B-D) Immunohistochemistry of the explant showing diffuse positivity for CD1a (B), Langerin/CD207 (C), and S100 (D). (E) PU.1 showing diffuse nuclear positivity. Bottom row: Allograft recurrence biopsy (29 January 2026). (F) Haematoxylin and eosin (x200). (G-J) CD1a (G), Langerin/CD207 (H), S100 (I), PU.1 (J). Scale bar 200x magnification. (Figure 2.)

Hu, Wang, Liu et al 2026, Frontiers in Medicine · CC BY 4.0

Immunohistochemistry staining of congenital Langerhans cell histiocytosis: (a) strong positive membranous immunostaining for CD1a (x40 magnification; scale bar = 100 um); (b) strong positive nuclear and cytoplasmic immunostaining for S100 (x40 magnification; scale bar = 200 um). (Figure 3.)

Abtahi-Naeini, Derakhshan, Emamjomeh et al 2025, Skin Health and Disease · CC BY 4.0

Tuberculoid leprosy: (a, b) Haematoxylin and eosin (H&E) stain showing superficial and deep dermal infiltration with non-caseating granulomas (black arrow) surrounded by numerous lymphocytes (white arrows) (a, x2; b, x4). (c) H&E; epidermal involvement with lymphocytic exocytosis (orange arrow) and absence of a grenz zone (x10). (d, e) H&E; perivascular granulomatous inflammation with abundant lymphocytes and Langhans-type giant cells (green arrows) (d, x20; e, x40). (f) Fite-Faraco stain: no acid-fast bacilli identified (x40). (FIGURE 3.)

van Wyk, le Grange, Budding et al 2026, Southern African Journal of Infectious Diseases · CC BY 4.0

Hematoxylin and Eosin (H&E) staining of myocardial tissue demonstrating a characteristic asteroid body. The black arrow highlights a distinct, star-shaped intracytoplasmic inclusion known as an asteroid body or stellate inclusion housed within a large multinucleated giant cell. These eosinophilic structures are frequently observed within granulomatous infiltrates on standard light microscopy. (human (myocardial tissue biopsy from a patient with cardiac sarcoidosis); Figure 5.)

Kancerek, Swierczek, Baron et al 2026, International Journal of Molecular Sciences · CC BY 4.0

Papers

  1. Homer RO, Isler M, Morley K, Stowman AM. Eosinophilic pustular folliculitis: The successful identification and treatment of clinically and histologically variable presentations. JAAD Case Rep. 2026;76:73-77. PMID: 42730266.
  2. Hu T, Wang C, Liu C, Sun J. Hepatobiliary langerhans cell histiocytosis mimicking Caroli syndrome and recurring in a liver allograft. Front Med (Lausanne). 2026;13:1898715. PMID: 42676998.
  3. Yamada S, Shimojima M, Saito T, Maruyama J, Kato H. Loss of type I interferon signaling in Kupffer cells triggers viral spread and fatal liver damage in a mouse model of Crimean-Congo hemorrhagic fever. PLoS Pathog. 2026;22:e1014511. PMID: 42611929.
  4. Halim D, McGrath E, Ampazis D, Krawczyk J, Shatwan R, O'Regan A. Not So Crystal Clear: Pulmonary Crystal-Storing Histiocytosis Without Haematological Disease: A Unique Radiological Manifestation and Review of the Literature. Diagnostics (Basel). 2026;16:2410. PMID: 42587647.
  5. van Wyk RB, le Grange DL, Budding L. A retrospective review of leprosy diagnosed histopathologically from skin biopsy specimens in central South Africa. S Afr J Infect Dis. 2026;41:802. PMID: 42428785.
  6. Kancerek J, Świerczek D, Baron W, Rojek M, Lewandowski P, Wojnicz R. Unmasking Cardiac Sarcoidosis: Integrating Multimodal Imaging with Histochemical and Ultrastructural Analysis. Int J Mol Sci. 2026;27:2969. PMID: 41977156.
  7. Abtahi-Naeini B, Derakhshan M, Emamjomeh A, Ghehsareh Ardestani A, Momenzadeh SS, Pourmahdi-Boroujeni M. Congenital solitary neck ulcer as a presentation of Langerhans cell histiocytosis. Skin Health Dis. 2025;5:394-398. PMID: 41035835.

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