Literature / Library / hepatocyte
hepatocyte
Real pictures of the hepatocyte delivered by gather.site, each with its paper.
7 pictures and 4 papers.
Gallery
Manipulation of bile canalicular localization in primary human hepatocytes cultured on claudin-coated plates. Hepatocytes were cultured on a plate coated with human claudin-1, -2, -3, and -9 (upper) and collagen alone as a control (lower). Immunofluorescence staining of MRP2 (red) was observed upon co-staining of the cell membrane marker WGA (green) and the nuclear marker DRAQ5 (blue). The white arrow indicates the bile canaliculi opened on the side of the culture equipment. Scale bar = 10 μm. (human (primary human hepatocytes); Figure 2, panel b.)
Arakawa et al. 2023, Communications Biology · CC BY 4.0
Morphology of human iPSC-derived hepatocytes (iHeps) during differentiation. Undifferentiated iPSC (Day 0) display oval/round shape; definitive endoderm (DE) and hepatic endoderm (HE) at intermediate stages; iHeps at Day 15 adopt characteristic polygonal morphology indicating successful hepatocyte differentiation. Both wild-type (WT) and MIC13-mutant cells shown. (human (iPSC-derived hepatocytes, patient-derived MIC13-mutant and WT lines); Figure 1, A.)
Becker A et al. 2026, Cell death & disease · CC BY 4.0
F-Actin co-localizes with the canalicular marker BSEP in bile canaliculi. Overview immunofluorescence images of human control liver tissue and liver from PSC patients showing BSEP-positive bile canaliculi with F-Actin co-staining. Both normal (control) and PSC-affected human hepatocytes are shown. (Homo sapiens; Figure S6 (extended data).)
Mayer C 2023, EMBO reports · CC BY 4.0
Localization of MRP2 in MYO5B-PFIC hepatocytes compared to healthy controls. Immunofluorescence showing normal apical MRP2 localization at bile canaliculi in healthy control human hepatocytes. Actin staining outlines the bile canaliculus with its microvilli. (Homo sapiens; Figure 7.)
Hess MW 2021, Journal of clinical medicine · CC BY 4.0
Localization of Myo5b in MYO5B-PFIC hepatocytes compared to healthy controls. Laser-scanning immunofluorescence micrographs showing regular bile canaliculus morphology in healthy control human hepatocytes, with myo5b at the apical plasma membrane and actin outlining the bile canaliculus with its microvilli. (Homo sapiens; Figure 5.)
Hess MW 2021, Journal of clinical medicine · CC BY 4.0
Ultrastructure and immuno-gold electron microscopy of aldehyde-fixed human liver biopsies. Control hepatocyte (panel b) shows normal bile canaliculus with microvilli, tight junctions, and surrounding hepatocyte membranes. MYO5B-PFIC patient sample (panel a) is shown for comparison alongside control canalicular ultrastructure. (Homo sapiens; Figure 9.)
Hess MW 2021, Journal of clinical medicine · CC BY 4.0
Hepatocytes of PSC patients accumulate apical bulkheads in bile canaliculi. Human liver tissue immunofluorescence showing ZO-1 (tight junction marker outlining bile canaliculi) and F-Actin co-staining. PSC patient hepatocytes show apical bulkheads compared to normal canalicular network. Scale bars indicated. (Homo sapiens; Figure 4.)
Mayer C 2023, EMBO reports · CC BY 4.0
Papers
- Becker A, Eichmann TO, Vasiliev V, Mey KA, Petzsch P, Rossi A, et al. MIC13-linked cristae disruption causes metabolic failure and early fibrotic remodelling in mitochondrial liver disease. Cell Death Dis. 2026;17:801. PMID: 42744797.
- Arakawa H, Nakazono Y, Matsuoka N, Hayashi M, Shirasaka Y, Hirao A, et al. Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion. Commun Biol. 2023;6:866. PMID: 37608051.
- Mayer C, Nehring S, Kücken M, Repnik U, Seifert S, Sljukic A, et al. Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease. EMBO Rep. 2023;24:e57181. PMID: 37522754.
- Hess MW, Krainer IM, Filipek PA, Witting B, Gutleben K, Vietor I, et al. Advanced Microscopy for Liver and Gut Ultrastructural Pathology in Patients with MVID and PFIC Caused by MYO5B Mutations. J Clin Med. 2021;10:1901. PMID: 33924896.